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- On pathology, herpes viruses causes a fulminant necrotizing meningoencephalitis and hemorrhagic. Typical gross findings include severe edema and massive tissue necrosis, petechial hemorrhages and with hemorrhagic necrosis. Often, the petechial hemorrhage is not Observed on CT or MRI. On microscopy, a focal necrotizing vasculitis is Observed with perivascular lymphocytic infiltration and meningeal and eosinophilic intranuclear inclusions in glial cells and neurons.
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